Introduction. The production of mineral fertilizers based on ammonia and carbamide has difficult and potentially dangerous working conditions. Modern estimates of production factors do not provide a complete picture of the harmfulness of working conditions. This is often due to time, financial, and laboratory and instrumental constraints. To date, there has not been a complete scientifically based comprehensive assessment of working conditions with the establishment of the influence of harmful factors of production on the health of workers. Objective. To carry out a hygienic assessment of working conditions, to establish the relationship of these factors with the state of health of industrial contingents of ammonia and carbamide production. Materials and methods. The factors of the production environment were studied with the establishment of a class of working conditions based on the results of laboratory tests of production control, inspections of the Rospotrebnadzor Department and a special assessment of working conditions. The health status was assessed by indicators of morbidity with temporary disability, chronic accumulated pathology, and the preservation of post-vaccination tetanus and diphtheria immunity in 971 "year-round" workers, taking into account the structural divisions of ammonia and carbamide production. Results of the study: It has been established that working conditions in the production of ammonia and carbamide are characterized as "harmful", with class 3.1 - 3.2. Morbidity with temporary disability and chronic accumulated pathology among workers employed in structural units with harmful working conditions is significantly higher (p