Conduction. Strengthening public health is the basis of the country's national security. Diseases of the circulatory system represent one of the most pressing health problems, being considered an epidemic of our time. The development of regional programs to improve public health should be based on monitoring the level and dynamics of this pathology. Goal. To analyze the dynamics of circulatory system disease incidence and mortality in the Astrakhan region for the period 2014-2023 in order to develop a regional program to strengthen public health. Material and methods. The source of information for the study was data from the Federal State Statistics Service and the Ministry of Health of the Astrakhan Region. When studying mortality from circulatory system diseases using the percentile method, the boundaries of the four quartiles into which the municipalities were divided were calculated. Methods: monographic, statistical, logical and systemic analysis. Results. The mortality rate of the population of the Astrakhan region from diseases of the circulatory system in 2023 compared to 2014 decreased by 11.3%. In three municipalities, mortality rates are significantly higher than in the region as a whole. The level of general morbidity over the study period increased by 34.1%, while six districts had rates above the average for the region. Primary morbidity rates were mixed. A comparison of average long-term mortality rates and general incidence of diseases of the circulatory system in the context of municipalities made it possible to identify areas with similar trends for the subsequent development of the necessary selective measures. Conclusion. In connection with the relevance of developing regional and municipal programs for strengthening public health aimed at combating risk factors for the development of chronic non-communicable diseases, it seems necessary to constantly monitor medical and demographic indicators both in the regions themselves and in municipalities.