Introduction. Menopause is a physiological stage of age-related changes, which is based on a natural age-related decrease in sex hormones and their subsequent normalization at a low level. At the same time, menopause is a period of increased risk of developing cardiovascular events and depressive episodes, which is associated with the interaction of biological and psychosocial factors. Menopausal hormone therapy is not considered as a method of primary cardiovascular prevention, which increases interest in non-drug interventions, primarily physical activity as a basic, affordable and economically justified strategy for the prevention of cardiovascular diseases in older women. The aim of the study was to evaluate the preventive effect of the original combined training program on vascular function and cardiometabolic parameters in menopausal women. Materials and methods. A randomized controlled trial was conducted with 95 women aged 45-55 years, divided into a control group with standard daily recommendations for physical activity (n=47) and a main group with the introduction of combined training programs (n=48). For 12 weeks, the main group performed a developed program, including interval aerobic, strength and breathing exercises. Results. In the main group, there was a statistically significant decrease in systolic blood pressure from 138.9±8.7 to 129.8±8.5 mmHg (p