Introduction. The quality of life (QoL) study is one of the ways to assess the overall condition of combat veterans and monitor the effectiveness of provided assistance, such as surgical treatment, rehabilitation measures, provision of medical drugs and rehabilitation tools, socialization in society, professional adaptation, etc. The aim of this survey: To assess the quality of life of combatants of combat veterans through a comprehensive evaluation of indicators reflecting various aspects of their daily functioning. The study is also aimed at identifying the domains most contributing to QoL reduction in order to facilitate future planning for planning the volume of medical care provided for veterans. Materials and methods. The study was conducted using a questionnaire-based survey employing the WHO QOL-100 instrument, which comprises six domains: physical health, psychological well-being, level of independence, social relationships, environmental factors, spiritual domain, as well as an overall quality-of-life assessment. Participants were combat veterans who had completed their service and sought medical assistance at the Center for Outpatient Medical Care for Participants of Special Military Operation, State Budgetary Healthcare Institution “GVV No. 3, Moscow Healthcare Department”. A total of 486 completed questionnaires were analyzed for this study. The influence of as specific life domains, on the overall QoL of combat veterans was examined. Statistical data processing was performed using Statistica for Windows and LibreOffice Calc. Results and discussion. The study revealed a significant decrease in QoL among veterans compared to the general population. Overall QoL was moderately reduced (by 28–34%) in the domains of “psychological well-being,” “level of independence,” “social relationships,” “environment,” “spiritual domain,” and “overall quality of life.” A particularly notable finding is the decrease in the “physical” domain (62.9% of respondents). Conclusion. The study found an overall decline in the quality of life of veterans across all assessed domains. The greatest impact on QoL reduction was observed in the domains of “physical health,” “level of independence,” and “environment.” The results of the quantitative quality of life assessment allow us to plan the necessary volumes of medical care and adjust the composition of personalized multidisciplinary teams based on individual needs.