Introduction. The versatility of the pathological processes underlying severe bronchial asthma (SBA) has led to the isolation of phenotypes and endotypes of the disease. For personalized accounting, a federal register of patients with SBA has been developed and implemented, and there are also a number of databases in this area. Meanwhile, when studying clinical features in SBA, the older age group is not given sufficient attention. Purpose of the study: to study the age-sex composition and the main clinical characteristics of patients with severe bronchial asthma receiving genetically engineered biological therapy (according to the Pulmonology Expert Center). Materials and methods. A retrospective clinical study was conducted on the data of medical records of 730 patients with SBA hospitalized in the Expert Center for the profile "Pulmonology," established on the basis of the St. Petersburg State Budgetary Healthcare Institution "City Multidisciplinary Hospital No. 2" in 2024. Descriptive and evaluation study was conducted in the context of SBA phenotypes (allergic, non-allergic and SBA with late onset) and age groups. Results. The most commonly prescribed genetically engineered biologic was dupilumab (52,8-60,4%). The allergic phenotype of SBA was characterized by the smallest median age (51,7), in the oldest patients the phenotype was associated with late onset of the disease. The comorbid background was most pronounced in patients with late onset SBA, with history of allergic reactions most common in allergic asthma. With age, the proportion of women among patients increased, and the incidence of age-associated concomitant diseases increased. In addition, the level of asthma control worsens with age. Discussion. Older age is a key aspect in choosing a strategy for curating patients with SBA, which may be due to a number of factors (comorbidity, polypharmacy, inflamaging, geriatric syndromes, etc.). Conclusion. With age, among patients with SBA, the frequency of a comorbid state increases, and the level of asthma control decreases. These patterns were characteristic of all SBA phenotypes considered.