Introduction. Medical information systems are widely used in medical practice, and the accumulated experience of their use requires analysis, an objective assessment of effectiveness and operational difficulties. In 2025, the Republic of Kazakhstan is completing the process of digitizing medical records, however, in order to realize the full potential of digitalization in healthcare, it is necessary to have modern, safe, cost-effective, ergonomic medical information systems updated to meet user requirements, changes in legislation, and technological advances. The purpose is to evaluate the effectiveness and ergonomics of the medical information system from the perspective of the main users. Materials and methods. The audit method was used to evaluate the integrated medical information system «Damu Med» in terms of the accuracy and completeness of electronic medical records. These parameters determine to what extent the data entered into the system corresponds to actual medical events and provides the necessary information for making clinical and managerial decisions. Results. A checklist was developed for the audit, which includes the following criteria: data accuracy, verification of compliance of the entered data with regulatory requirements and standards for maintaining medical records, completeness of data filling, and quality of record keeping. The audit of electronic medical records revealed a high level of congruence for the categories "Patient data", "Compliance with clinical protocols", and "Quality of record keeping" (95%, 85%, and 80%, respectively). Shortcomings in filling out the dynamics of the condition, specifying dosages in prescriptions, polypragmasy, systematic gaps in filling out the medical history, documenting the dynamics of the condition and prescriptions, as well as deviations from clinical protocols were identified. Conclusion. The evaluation of the effectiveness of the IIA should be individual and adapted to the specific conditions and tasks of the organization. The results of the audit of electronic medical records have demonstrated that the introduction of IIAS has led to an increase in the reliability and efficiency of accounting for medical data. The proposed measures to improve the IIA are aimed at improving the accuracy and completeness of medical records management, as well as improving the internal control system and patient feedback. The introduction of automated functions, standard templates, and regular audits, as well as training activities, will improve the quality of records and provide a higher level of medical care.