Introduction (relevance): the study of pre-disease conditions, especially in the context of heart failure with preserved ejection fraction (HF-PEF), is due to its prevalence and association with increased morbidity and mortality. The pre-stage of CHF is characterized by the absence of symptoms in the presence of structural/functional changes in the heart or elevated NT-proBNP. Left ventricular diastolic dysfunction is a key element of pathogenesis. Identification of risk factors (age, gender, obesity, hypertension, smoking, diabetes, coronary heart disease, COPD) is important for prevention. In the Russian Federation, the main causes of CHF are hypertension and coronary heart disease. Purpose of the study: evaluation of examination data of 55-year-old female patients taking into account the domain approach with an increase in NT-proBNP and correlating nosologies. Materials and methods: the parameters of the somatic (anthropometry, blood pressure, heart rate, complete blood count, biochemistry, echocardiography, "Cardiovisor", SVVR, drug therapy), locomotor (FRAIL, Katz scales, hand strength, SARC-F, BIA), sensory (ophthalmological examination), cognitive (MMSE), psychological (Beck and SHAS scales) and nutritional (MNA) domains were studied. The following methods were used: "Cardiovisor", EchoCG (Toshiba Aplio 500), Holter-DMS (HRV), determination of NLR and PLR, HbA1c (HPLC), CRP (spectrophotometry), omega-3 index (gas chromatography), FRAIL, Katz, MNA scales, dynamometry (Jamar), BIA (ACCUNIQ), ophthalmological examination (Topcon TRC NW6s, RTVue XP), MMSE, Beck scales and SHAS. Statistical analysis was performed in StatTech 4.8.0. Results and discussion. Evaluation of examination data of 100 55-year-old female patients with elevated NT-proBNP requires exclusion of underlying causes (heart failure, coronary heart disease, hypertension) and comprehensive analysis by domains (cardiovascular, renal, endocrine systems, concomitant diseases). If deviations are detected, an in-depth examination is necessary to establish a diagnosis and develop an individual treatment plan. Regular monitoring of NT-proBNP is important for assessing the effectiveness of therapy. Conclusion. The data provided show that the level of N-terminal natriuretic peptide type B (NT-proBNP) is an important biomarker for assessing the risk of various conditions associated with age-related changes in the body within the domain approach and, therefore, can be used in matters of primary and secondary geroprophylaxis.