Introduction. Modern dermatology and cosmetology strive to find effective methods to slow down age-related changes and restore the skin using innovative technologies and drugs. However, there is insufficient data in the scientific literature on the comprehensive assessment of the effectiveness of popular methods for correcting skin aging using clinical, instrumental, immunohistochemical and immunological methods. The purpose is to characterize the effectiveness of human placenta hydrolysate preparations and fractional laser photothermolysis in correcting signs of skin aging. Materials and methods. In 50 conditionally healthy women with signs of age-related skin changes, divided into two groups, a course of intramuscular injections of the HP Laennek drug (group 1) and fractional laser photothermolysis (group 2) were performed. Before the course of treatment, on the 8th and 24th days after treatment, women were assessed for indicators of systemic immunity, skin parameters using a dermoscanner, and immunohistochemical examination of skin structures. Results. A comprehensive study of the immune status of women after cosmetic facial rejuvenation shows that, despite the similarity of the immune system's reactions to the methods used, a course of injections of human placenta hydrolysate reduces the severity and duration of inflammatory reactions compared with fractional laser photothermolysis. Placenta hydrolysate preparation and fractional laser photothermolysis are effective in correcting age-related skin changes in women: they reduce the depth of wrinkles, improve the contour of the face and increase hydration. Conclusion. The results of a comprehensive assessment of the immune status of women after various methods of cosmetic skin rejuvenation show that despite the similarity of immune reactions to biological therapy, laser procedure and their combination, injections of human placenta hydrolysate before laser exposure can reduce the severity and duration of inflammatory reactions in fractional laser photothermolysis, exerting a regulating effect on the balance of pro-inflammatory and anti-inflammatory factors.